Looking forward to going home to Canada and joining fellow neuroscientists at Canadian Association for Neuroscience's 2014 Conference in Montreal, QC.
I'll be presenting my work titled: "TrkB receptor activity in the olfactory bulb is needed for long-term memory of odour-reward learning"
I'll also enjoying being able to say "aboot" and "zed-score" without much commotion!
ABSTRACT: Understanding the molecular mechanisms underlying long-term memory (LTM) has been a long-standing goal in neuroscience. It is well established that LTM requires protein synthesis whereas short-term memory (STM) does not. While specific proteins have been identified as crucial for LTM consolidation, what remains unclear is the specific time course of their involvement, particularly in multi-trial appetitive learning. To further explore this idea, we examine the time course of brain-derived neurotrophic factor (BDNF) activity in an olfactory bulb (OB)-dependent incremental learning task. BDNF is a strong candidate due to its established involvement in promoting neuron survival, the activity-dependent nature of its secretion, and its established effect on OB-dependent learning mechanisms (Bath, Mandairon, Jing, Rajagopal, Kapoor, Chen, Khan, Proenca, Kraemer, Cleland, Hempstead, Chao, & Lee 2008). Its expression immediately after learning also has been shown to be necessary for LTM consolidation, but not for STM (Alonso et al., 2005, Learn Mem). In the present study, animals were trained over several trials to learn an odour-reward association and memory was probed 48 hours later. We found that, compared to controls, mice infused with the BDNF receptor antagonist K252a into the OB prior to training showed impaired memory at 48 hours. This finding suggests that activation of the BDNF-TrkB pathway is necessary for the consolidation of OB-dependent LTM.